YB-1/YBX1 Polyclonal Antibody
- SKU:
- CAB6799
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | YB-1/YBX1 Polyclonal Antibody |
| Product Code: | CAB6799 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:20-1:50 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | 293T |
| Cellular Location: | Cytoplasm, Cytoplasmic granule, Nucleus, Secreted |
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human YB-1/YBX1 (NP_004550.2). |
| Sequence: | MSSEA ETQQP PAAPP AAPAL SAADT KPGTT GSGAG SGGPG GLTSA APAGG DKKVI |
| Synonyms: | YB1, BP-8, CSDB, DBPB, YB-1, CBF-A, CSDA2, EFI-A, NSEP1, NSEP-1, MDR-NF1 |
| Calculated MW: | 36kDa |
| Observed MW: | 50kDa |
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