PHGDH Monoclonal Antibody
- SKU:
- CAB22129
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | PHGDH Monoclonal Antibody |
| Product Code: | CAB22129 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55949 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:20000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, MCF7, Daudi(negative), Mouse brain, Mouse thymus, Rat brain, Rat testis |
| Cellular Location: | cytosol, extracellular exosome |
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 264-533 of human PHGDH (NP_006614.2). |
| Sequence: | EEPPR DRALV DHENV ISCPH LGAST KEAQS RCGEE IAVQF VDMVK GKSLT GVVNA QALTS AFSPH TKPWI GLAEA LGTLM RAWAG SPKGT IQVIT QGTSL KNAGN CLSPA VIVGL LKEAS KQADV NLVNA KLLVK EAGLN VTTSH SPAAP GEQGF GECLL AVALA GAPYQ AVGLV QGTTP VLQGL NGAVF RPEVP LRRDL PLLLF RTQTS DPAML PTMIG LLAEA GVRLL SYQTS LVSDG ETWHV MGISS LLPSL EAWKQ HVTEA FQFHF |
| Synonyms: | NLS, PDG, PGD, NLS1, PGAD, PGDH, SERA, 3PGDH, 3-PGDH, PHGDHD, HEL-S-113 |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
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