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PE Anti-Mouse CD49b Antibody [DX5] (AGEL1446)

Datasheet MSDS
SKU AGEL1446
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone DX5
Conjugation PE

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Description

system_update_altDatasheetsystem_update_altMSDS

PE Anti-Mouse CD49b Antibody [DX5]

The Mouse CD49b Monoclonal Antibody (PE-Conjugated, DX5, AGEL1446) is a specialized tool for researchers investigating CD49b, a cell surface marker primarily found on natural killer cells and a subset of T cells. This monoclonal antibody, conjugated with PE for fluorescent detection, has been rigorously tested and validated for flow cytometry applications in mouse samples.CD49b, also known as α2 integrin, plays a crucial role in cell adhesion and migration, particularly in the context of immune responses and tissue repair. Its presence on specific immune cell populations makes it a valuable target for immunology studies, ranging from understanding immune surveillance mechanisms to investigating immune cell recruitment to inflammatory sites.

By using the Mouse CD49b Monoclonal Antibody (PE-Conjugated, DX5, AGEL1446), researchers can accurately identify and quantitate CD49b-expressing cells, enabling detailed analysis of immune cell populations in various experimental settings. This antibody is an essential tool for advancing knowledge in immunology, inflammation, and immune cell biology.

Product Title:PE Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL1446
Size:25µg, 100µg
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:PE Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.
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