macroH2A.1 Polyclonal Antibody
- SKU:
- CAB21836
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | macroH2A.1 Polyclonal Antibody |
| Product Code: | CAB21836 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Chromosome, Nucleus |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human macroH2A.1 (NP_613258.2). |
| Sequence: | IHSEI SNLAG FEVEA IINPT NADID LKDDL GNTLE KKGGK EFVEA VLELR KKNGP LEVAG AAVSA GHGLP AKFVI HCNSP VWGAD KCEEL LEKTV KNCLA L |
| Synonyms: | H2A.y, H2A/y, H2AFY, mH2A1, H2AF12M, MACROH2A1.1, macroH2A1.2 |
| Calculated MW: | 39kDa |
| Observed MW: | Refer to figures |
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