Human VTA1 Recombinant Protein (RPPB5139)

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RPPB5139

Description

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Product Name:Human VTA1 Recombinant Protein
Product Code:RPPB5139
Size:20µg
Species:Human
Target:VTA1
Synonyms:Vacuolar protein sorting-associated protein VTA1 homolog, DRG-1, LYST-interacting protein 5, LIP5, SKD1-binding protein 1, SBP1, VTA1, C6orf55, DRG1My012, HSPC228.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:VTA1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 10% glycerol and 200mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAALAP LPPLPAQFKS IQHHLRTAQE HDKRDPVVAY YCRLYAMQTG MKIDSKTPEC RKFLSKLMDQ LEALKKQLGD NEAITQEIVG CAHLENYALK MFLYADNEDR AGRFHKNMIK SFYTASLLID VITVFGELTD ENVKHRKYAR WKATYIHNCL KNGETPQAGP VGIEEDNDIE ENEDAGAASL PTQPTQPSSS STYDPSNMPS GNYTGIQIPP GAHAPANTPA EVPHSTGVAS NTIQPTPQTI PAIDPALFNT ISQGDVRLTP EDFARAQKYC KYAGSALQYE DVSTAVQNLQ KALKLLTTGR E

Vps20-associated 1 homolog (VTA1) is a member of the VTA1 family. The VTA1 protein is involved in the endosomal multivesicular bodies (MVB) pathway. Furthermore, VTA1 is interacts with CHMP1B, CHMP2A, CHMP5, VPS4B, KIAA0174 (IST1) and possibly CHMP3. VTA1 is believed to be a cofactor of VPS4A/B, which catalyzes membrane-associated ESCRT-III assemblies. In addition, VTA1 is involved in the sorting and down-regulation of EGFR and also in HIV-1 budding.

VTA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 331 amino acids (1-307 a.a.) and having a molecular mass of 36.5kDa.VTA1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:VTA1: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding. Belongs to the VTA1 family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 6q24.1

Cellular Component: endosome membrane; cytosol

Molecular Function:protein binding

Biological Process: protein transport; viral reproduction; viral infectious cycle; endosome transport

NCBI Summary:C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9NP79
NCBI GenInfo Identifier:30580379
NCBI Gene ID:51534
NCBI Accession:Q9NP79.1
UniProt Related Accession:Q9NP79
Molecular Weight:
NCBI Full Name:Vacuolar protein sorting-associated protein VTA1 homolog
NCBI Synonym Full Names:vesicle trafficking 1
NCBI Official Symbol:VTA1��
NCBI Official Synonym Symbols:DRG1; LIP5; SBP1; DRG-1; My012; C6orf55; HSPC228��
NCBI Protein Information:vacuolar protein sorting-associated protein VTA1 homolog
UniProt Protein Name:Vacuolar protein sorting-associated protein VTA1 homolog
UniProt Synonym Protein Names:Dopamine-responsive gene 1 protein; DRG-1; LYST-interacting protein 5; LIP5; SKD1-binding protein 1; SBP1
Protein Family:Vacuolar protein sorting-associated protein
UniProt Gene Name:VTA1��
UniProt Entry Name:VTA1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NP79
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