Human VAMP8 Recombinant Protein (RPPB5109)

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RPPB5109

Description

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Product Name:Human VAMP8 Recombinant Protein
Product Code:RPPB5109
Size:25µg
Species:Human
Target:VAMP8
Synonyms:VAMP8, VAMP-8, Endobrevin, Vesicle-Associated Membrane Protein 8, EDB.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The VAMP8 protein solution (0.25mg/ml) contains 20mM Tris pH-8, 0.1mM PMSF, 0.2M NaCl and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEEASEGGGN DRVRNLQSEV EGVKNIMTQN VERILARGEN LEHLRNKTED LEATSEHFKT TSQKVARKFW WKNVKM

VAMP8 also called endobrevin, is the main component of a SNARE complex involved in the docking and fusion of synaptic vesicles with the presynaptic membrane. VAMP8 protein is involved in the regulatation of enzyme secretion in pancreatic acinar cells and plays a part in the abscission of the midbody during cell division, which leads to completely separate daughter cells. VAMP8 is essential for dense-granule secretion in platelets. VAMP8 is related with the perinuclear vesicular structures of the early endocytic compartment. VAMP8 interacts particularly with the soluble NSF-attachment protein (alpha-SNAP), through an VAMP8-containing SNARE complex.

VAMP8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 96 amino acids (1-76 a.a.) and having a molecular mass of 10.9 kDa. The VAMP8 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatography techniques.

UniProt Protein Function:VAMP8: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 2p12-p11.2

Cellular Component: cytoplasm; cytosol; early endosome; late endosome membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome; secretory granule membrane; SNARE complex; vesicle

Molecular Function:chloride channel inhibitor activity; protein binding; SNAP receptor activity; SNARE binding

Biological Process: entry of virus into host cell; eosinophil degranulation; neutrophil degranulation; post-Golgi vesicle-mediated transport; vesicle fusion

NCBI Summary:This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
UniProt Code:Q9BV40
NCBI GenInfo Identifier:55976764
NCBI Gene ID:8673
NCBI Accession:Q9BV40.1
UniProt Secondary Accession:Q9BV40,O60625, Q53SP9, Q6IB09,
UniProt Related Accession:Q9BV40
Molecular Weight:11,438 Da
NCBI Full Name:Vesicle-associated membrane protein 8
NCBI Synonym Full Names:vesicle associated membrane protein 8
NCBI Official Symbol:VAMP8��
NCBI Official Synonym Symbols:EDB; VAMP-8��
NCBI Protein Information:vesicle-associated membrane protein 8
UniProt Protein Name:Vesicle-associated membrane protein 8
UniProt Synonym Protein Names:Endobrevin
Protein Family:Vesicle-associated membrane protein
UniProt Gene Name:VAMP8��
UniProt Entry Name:VAMP8_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BV40
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