Human TMOD3 Recombinant Protein (RPPB4974)

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RPPB4974

Description

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Product Name:Human TMOD3 Recombinant Protein
Product Code:RPPB4974
Size:10µg
Species:Human
Target:TMOD3
Synonyms:Tropomodulin-3, Ubiquitous tropomodulin, U-Tmod, TMOD3, UTMOD.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TMOD3 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMALPFR KDLEKYKDLD EDELLGNLSE TELKQLETVL DDLDPENALL PAGFRQKNQT SKSTTGPFDR EHLLSYLEKE ALEHKDREDY VPYTGEKKGK IFIPKQKPVQ TFTEEKVSLD PELEEALTSA SDTELCDLAA ILGMHNLITN TKFCNIMGSS NGVDQEHFSN VVKGEKILPV FDEPPNPTNV EESLKRTKEN DAHLVEVNLN NIKNIPIPTL KDFAKALETN THVKCFSLAA TRSNDPVATA FAEMLKVNKT LKSLNVESNF ITGVGILALI DALRDNETLA ELKIDNQRQQ LGTAVELEMA KMLEENTNIL KFGYQFTQQG PRTRAANAIT KNNDLVRKRR VEGDHQ

Tropomodulin 3 (TMOD3) is a member of the tropomodulin family. TMOD3 prevents the elongation and depolymerization of the actin filaments at the pointed end. Actin cytoskeleton regulation by filament capping proteins is essential to many dynamic cellular functions. TMOD3 functions as a negative regulator of cell migration; nevertheless the processes behind its cellular functions are unknown. The Tmod/TM complex influences the formation of the short actin protofilament, which sequentially outlines the geometry of the membrane skeleton.

TMOD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 376 amino acids (1-352 a.a) and having a molecular mass of 42kDa.TMOD3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TMOD3: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. Belongs to the tropomodulin family.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q21.1-q21.2

Cellular Component: striated muscle thin filament

Molecular Function:actin binding; tropomyosin binding

Biological Process: erythrocyte development; myofibril assembly; muscle contraction; actin filament organization; pointed-end actin filament capping

UniProt Code:Q9NYL9
NCBI GenInfo Identifier:23396884
NCBI Gene ID:29766
NCBI Accession:Q9NYL9.1
UniProt Related Accession:Q9NYL9
Molecular Weight:
NCBI Full Name:Tropomodulin-3
NCBI Synonym Full Names:tropomodulin 3
NCBI Official Symbol:TMOD3��
NCBI Official Synonym Symbols:UTMOD��
NCBI Protein Information:tropomodulin-3
UniProt Protein Name:Tropomodulin-3
UniProt Synonym Protein Names:Ubiquitous tropomodulin; U-Tmod
Protein Family:Tropomodulin
UniProt Gene Name:TMOD3��
UniProt Entry Name:TMOD3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NYL9
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