Human RPS3A Recombinant Protein (RPPB4508)

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RPPB4508

Description

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Product Name:Human RPS3A Recombinant Protein
Product Code:RPPB4508
Size:20µg
Species:Human
Target:RPS3A
Synonyms:Ribosomal protein S3A, v-fos transformation effector protein 1, 40S ribosomal protein S3a, MFTL, FTE1, S3A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RPS3A solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAVGKN KRLTKGGKKG AKKKVVDPFS KKDWYDVKAP AMFNIRNIGK TLVTRTQGTK IASDGLKGRV FEVSLADLQN DEVAFRKFKL ITEDVQGKNC LTNFHGMDLT RDKMCSMVKK WQTMIEAHVD VKTTDGYLLR LFCVGFTKKR NNQIRKTSYA QHQQVRQIRK KMMEIMTREV QTNDLKEVVN KLIPDSIGKD IEKACQSIYP LHDVFVRKVK MLKKPKFELG KLMELHGEGS SSGKATGDET GAKVERADGY EPPVQESV

RPS3A is a member of the S3AE family of ribosomal proteins. Ribosomes, the organelles which catalyze protein synthesis, composed of a large 60S subunit and a small 40S subunit. Together these subunits consist of 4 RNA classes and around 80 structurally diverse proteins. RPS3A, a component of the 40S subunit, is a ribosomal protein that is situated in the cytoplasm. Interference of the gene encoding rat ribosomal protein S3a, in v-fos-transformed rat cells cause a degeneration of the transformed phenotype.

RPS3A Human Recombinant produced in E. coli is a single polypeptide chain containing 288 amino acids (1-264) and having a molecular mass of 32.5kDa.RPS3A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RPS3A: ribosomal protein S3a. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Belongs to the S3AE family of ribosomal proteins. Located in the cytoplasm. Also named v-fos transformation effector protein.
UniProt Protein Details:

Protein type:Ribosomal; Translation

Chromosomal Location of Human Ortholog: 4q31.2-q31.3

Cellular Component: focal adhesion; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex; cytosol

Molecular Function:protein binding; structural constituent of ribosome; RNA binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translational elongation; viral reproduction; translation; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; translational termination; viral infectious cycle; cell differentiation; negative regulation of apoptosis

NCBI Summary:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
UniProt Code:P61247
NCBI GenInfo Identifier:47117764
NCBI Gene ID:6189
NCBI Accession:P61247.2
UniProt Secondary Accession:P61247,P33443, P49241, B2R4D4, D3DP05,
UniProt Related Accession:P61247
Molecular Weight:264
NCBI Full Name:40S ribosomal protein S3a
NCBI Synonym Full Names:ribosomal protein S3A
NCBI Official Symbol:RPS3A��
NCBI Official Synonym Symbols:S3A; FTE1; MFTL��
NCBI Protein Information:40S ribosomal protein S3a; RPS3A; fte-1; v-fos transformation effector protein 1
UniProt Protein Name:40S ribosomal protein S3a
UniProt Synonym Protein Names:v-fos transformation effector protein; Fte-1
Protein Family:40S ribosomal protein
UniProt Gene Name:RPS3A��
UniProt Entry Name:RS3A_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P61247
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