Human PPM1A Recombinant Protein (RPES1769)
- SKU:
- RPES1769
- Product Type:
- Recombinant Protein
- Species:
- Human
Frequently bought together:
Description
system_update_altDatasheet
Human PPM1A Recombinant Protein
Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also; it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3; resulting in their dissociation from SMAD4; nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition; PPM1A can dephosphorylate cyclin-dependent kinases; and thus may be involved in cell cycle control.
| Product Name: | Human PPM1A Recombinant Protein (RPES1769) |
| Product Code: | RPES1769 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Protein Phosphatase 1A, Protein Phosphatase 2C Isoform Alpha, PP2C-Alpha, Protein Phosphatase IA, PPM1A, PPPM1A,PP2C-ALPHA,PP2CA,PP2Calpha |
| Accession: | P35813-1 |
| Sequence: | Gly2-Trp382 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Protein Phosphatase 1A is produced by our E.coli expression system and the target gene encoding Gly2-Trp382 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 43.5 kDa |
| AP Mol Mass: | 45 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.4. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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