Cytokines Recombinant Proteins

Human IL4R Recombinant Protein (RPPB0514)

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RPPB0514

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human IL4R Recombinant Protein
Product Code:RPPB0514
Size:15µg
Species:Human
Target:IL4R
Synonyms:Interleukin 4 Receptor, IL-4 Receptor Subunit Alpha, Interleukin 13 Receptor, IL-4RA, IL4RA, Interleukin-4 Receptor Subunit Alpha, Interleukin-4 Receptor Alpha Chain, IL4R Nirs Variant 1, IL-4R Subunit Alpha, CD124 Antigen, IL-4R-Alpha, CD124, IL4R.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL4R protein solution (0.25mg/ml) contains Phosphate buffered saline (pH7.4).�
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKVLQEPTCV SDYMSISTCE WKMNGPTNCS TELRLLYQLV FLLSEAHTCI PENNGGAGCV CHLLMDDVVS ADNYTLDLWA GQQLLWKGSF KPSEHVKPRA PGNLTVHTNV SDTLLLTWSN PYPPDNYLYN HLTYAVNIWS ENDPADFRIY NVTYLEPSLR IAASTLKSGI SYRARVRAWAQCYNTTWSEW SPSTKWHNSY REPFEQHLEH HHHHH

IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

IL4R produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (26-232 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 215 amino acids and having a molecular mass of 24.7kDa.IL4R shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

UniProt Protein Function:Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
NCBI Summary:This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
UniProt Code:P24394
NCBI GenInfo Identifier:124335
NCBI Gene ID:3566
NCBI Accession:P24394.1
UniProt Secondary Accession:P24394,Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185 Q9H186, Q9H187, B4E076, B9EKU8, H3BSY5,
UniProt Related Accession:P24394
Molecular Weight:88,267 Da
NCBI Full Name:Interleukin-4 receptor subunit alpha
NCBI Synonym Full Names:interleukin 4 receptor
NCBI Official Symbol:IL4R��
NCBI Official Synonym Symbols:CD124; IL4RA; IL-4RA��
NCBI Protein Information:interleukin-4 receptor subunit alpha
UniProt Protein Name:Interleukin-4 receptor subunit alpha
UniProt Synonym Protein Names:CD_antigen: CD124
Protein Family:Interleukin
UniProt Gene Name:IL4R��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P24394
Research Area:
Cytokines
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