GNA11 Polyclonal Antibody
- SKU:
- CAB19313
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | GNA11 Polyclonal Antibody |
| Product Code: | CAB19313 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Cytoplasm, Lipid-anchor |
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human GNA11 (NP_002058.2). |
| Sequence: | ESKAL FRTII TYPWF QNSSV ILFLN KKDLL EDKIL YSHLV DYFPE FDGPQ RDAQA AREFI LKMFV DLNPD SDKII YSHFT CATDT ENIRF VFAAV KDTIL Q |
| Synonyms: | FBH, FBH2, FHH2, HG1K, HHC2, GNA-11, HYPOC2 |
| Calculated MW: | 42kDa |
| Observed MW: | Refer to figures |
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