BID Monoclonal Antibody [P4D3AT] (CPAB0536)
![BID Monoclonal Antibody [P4D3AT] (CPAB0536)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58757/63939/bid-monoclonal-antibody-p4d3at-cpab0536__78073__67500.1706535208.jpg?c=1 "BID Monoclonal Antibody [P4D3AT] (CPAB0536)")
- SKU:
- CPAB0536
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- P4D3AT
- Applications:
- WB
- Applications:
- ELISA
![BID Monoclonal Antibody [P4D3AT] (CPAB0536)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58757/63939/bid-monoclonal-antibody-p4d3at-cpab0536__78073__67500.1706535208.jpg?c=1&imbypass=on "BID Monoclonal Antibody [P4D3AT] (CPAB0536)")
Description
system_update_alt Datasheet
| Product Name: | BID Antibody |
| Product Sku: | CPAB0536 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human BID mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human BID amino acids 1-195 purified from Ecoli. |
| Clone: | P4D3AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | BID antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG1 |
| Background: | BID accession number NP_001187 is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which leads to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis. |
| Synonyms: | BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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