Developmental Biology
Anti-ZP1 Antibody (CAB10776)
- SKU:
- CAB10776
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-ZP1 Antibody |
| Antibody SKU: | CAB10776 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human ZP1 (NP_997224.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | OVCAR8, OVCAR3, SKOV3, NCI-H460, A-549, Mouse lung, Rat ovary, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human ZP1 (NP_997224.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AGDQ LIYE NWLV SGIH IQKG PQGS ITRD STFQ LHVR CVFN ASDF LPIQ ASIF PPPS PAPM TQPG PLRL ELRI AKDE TFSS YYGE DDYP IVRL LREP VHVE VRLL QRTD PNLV LLLH QCWG APSA NPFQ QPQW PILS DGCP FKGD SYRT QMVA LDGA TPFQ SHYQ RFTV ATFA LLDS GSQR ALRG LVYL FCST SACH TSGL ETCS TACS TGTT RQRR SSGH RNDT ARPQ DIVS SPGP VGFE DSYG QEPT LGPT DSNG NSSL RPLL WAVL LLP |
| Gene ID: | 22917 |
| Uniprot: | P60852 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein, extracellular matrix, extracellular space |
| Calculated MW: | 70kDa |
| Observed MW: | 70kDa |
| Synonyms: | ZP1, HEL163, OOMD, OOMD1 |
| Background: | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. |
| UniProt Protein Function: | ZP1: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. Belongs to the ZP domain family. ZPB subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 11q12.2 Cellular Component: extracellular region Biological Process: binding of sperm to zona pellucida Disease: Oocyte Maturation Defect |
| NCBI Summary: | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014] |
| UniProt Code: | P60852 |
| NCBI GenInfo Identifier: | 46397079 |
| NCBI Gene ID: | 22917 |
| NCBI Accession: | P60852.1 |
| UniProt Related Accession: | P60852 |
| Molecular Weight: | 70kDa |
| NCBI Full Name: | Zona pellucida sperm-binding protein 1 |
| NCBI Synonym Full Names: | zona pellucida glycoprotein 1 |
| NCBI Official Symbol: | ZP1 |
| NCBI Official Synonym Symbols: | OOMD; OOMD1; HEL163 |
| NCBI Protein Information: | zona pellucida sperm-binding protein 1 |
| UniProt Protein Name: | Zona pellucida sperm-binding protein 1 |
| UniProt Synonym Protein Names: | Zona pellucida glycoprotein 1; Zp-1 |
| Protein Family: | Zona pellucida sperm-binding protein |
| UniProt Gene Name: | ZP1 |
 | Western blot analysis of extracts of various cell lines, using ZP1 antibody (CAB10776) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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