Cardiovascular Antibodies

VAV3 Rabbit Polyclonal Antibody (CAB15385)

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SKU:
CAB15385
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
Reactivity:
Human, Mouse
Synonyms:
VAV3
Research Use:
Cardiovascular
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Description

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VAV3 Antibody (CAB15385)

The VAV3 Antibody (CAB15385) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.With its ability to specifically bind to the VAV3 protein, this antibody enables researchers to detect and analyze VAV3 expression in a variety of cell types, allowing for in-depth investigation into its role in signaling cascades and its potential implications in cancer progression and other diseases.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:VAV3 Antibody
SKU:CAB15385
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:DNCG RVNS GEQG TLKL PEKR TNGL RRTP KQVD PGLP KMQV IRNY SGTP PPAL HEGP PLQL QAGD TVEL LKGD AHSL FWQG RNLA SGEV GFFP SDAV KPCP CVPK PVDY SCQP WYAG AMER L
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:200 - 1:2000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:VAV3
Positive Sample:Jurkat, Mouse brain, Mouse lung, Mouse spleen
Cellular Localization:Cytoplasm, Cytosol, Immunological Synapse, Plasma Membrane.
Calculated MW:98kDa
Observed MW:105kDa

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Purification MethodAffinity purification
Gene ID10451
RRIDAB_2762291
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using VAV3 Rabbit pAb (CAB15385) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 2s.
Product ImageImmunofluorescence analysis of HeLa cells using VAV3 Rabbit pAb (CAB15385) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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