Cell Biology Antibodies 6

UNC13B Rabbit Polyclonal Antibody (CAB15780)

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SKU:
CAB15780
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse
Synonyms:
UNC13, MUNC13, Unc13h2, munc13-2, UNC13B
Research Use:
Cell Biology
Frequently bought together:

Description

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UNC13B Antibody (CAB15780)

The UNC13B Antibody (CAB15780) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards UNC13B in human samples, making it ideal for use in Western blot applications. By targeting UNC13B, researchers can investigate its role in neuronal communication and potential implications in neurological disorders such as epilepsy, schizophrenia, and Alzheimer's disease.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:UNC13B Antibody
SKU:CAB15780
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MSLL CVRV KRAK FQGS PDKF NTYV TLKV QNVK STTV AVRG DQPS WEQD FMFE ISRL DLGL SVEV WNKG LIWD TMVG TVWI ALKT IRQS DEEG PGEW STLE AETL MKDD EICG TRNP TPHK ILLD TRFE LPFD IPEE EARY WTYK WEQI NALG ADNE YSSQ EESQ RKPL PTAA AQCS FEDP DSAV DDRD SDYR SETS NSFP PPYH TASQ PNAS VHQF PVPV RSPQ QLLL QGSS RDSC NDSM QSYD LDYP ERRA ISPT SSSR YGSS CNVS QGSS QLSE LDQY HEQD DDHR ETDS IHSC HSSH SLSR DGQA GFGE QEKP LEVT GQAE KEAA CEPK EMKE DATT HPPP DLVL QK
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:UNC13, MUNC13, Unc13h2, munc13-2, UNC13B
Positive Sample:293T, LO2
Cellular Localization:Cell Junction, Cell Membrane, Cytoplasm, Membrane, Peripheral Membrane Protein, Synapse.
Calculated MW:181kDa
Observed MW:210kDa

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

Purification MethodAffinity purification
Gene ID10497
RRIDAB_2763200
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using UNC13B Rabbit pAb (CAB15780) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human liver using UNC13B Rabbit pAb (CAB15780) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
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