Description
UGT1A6 Antibody (CAB17166)
The UGT1A6 Antibody (CAB17166) is a high-quality antibody developed for reliable detection and analysis of target proteins. Raised in rabbits, this antibody demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to UGT1A6, this antibody facilitates the detection and analysis of the enzyme in various cell types, making it a crucial component for investigations in pharmacology and toxicology research.
This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.
| Product Name: | UGT1A6 Antibody |
| SKU: | CAB17166 |
| Size: | 20μL, 100μL |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||||
| Sequence: | LLLK ESKY YTRK IYPV PYDQ EELK NRYQ SFGN NHFA ERSF LTAP QTEY RNNM IVIG LYFI NCQS LLQD RDTL NFFK ESKF DALF TDPA LPCG VILA EYLG LPSV YLFR GFPC SLEH TFSR SPDP VSYI PRCY TKFS DHMT FSQR VANF LVNL LEPY LFYC LFSK YEEL ASAV LKRD VDII TLYQ KVSV WLLR YDFV LEYP RPVM PN | ||||||
| Tested Applications: | WB ELISA IF-P | ||||||
| Recommended Dilution: |
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| Synonyms: | GNT1, UGT1, HLUGP, UDPGT, UGT1A, UGT1C, UGT1E, UGT1F, HLUGP1, UGT-1A, UGT-1C, UGT-1E, UGT-1F, UGT1.1, UGT1.3, UGT1.5, UGT1.6, UGT1A1, UGT1A3, UGT1A5, UGT1-01, UGT1-03, UGT1-05, UGT1-06, UGT1A6S, hUG-BR1, UDPGT 1-6, UGT1A6 |
| Positive Sample: | A-431, HT-29, Mouse liver, Mouse kidney |
| Cellular Localization: | Endoplasmic Reticulum Membrane, Microsome, Single-Pass Membrane Protein. |
| Calculated MW: | 61kDa |
| Observed MW: | 70kDa |
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
| Purification Method | Affinity purification |
| Gene ID | 54578 |
| RRID | AB_2772805 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using UGT1A6 Rabbit pAb (CAB17166) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s. |
 | Immunofluorescence analysis of paraffin-embedded rat liver using UGT1A6 Rabbit pAb (CAB17166) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining. |
