KO Validated Antibodies 2
Anti-TTC11 Antibody [KO Validated] (CAB19666)
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![Anti-TTC11 Antibody [KO Validated] (CAB19666)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/55986/61168/anti-ttc11-antibody-ko-validated-cab19666__81337__17498.1706533728.jpg?c=1 "Anti-TTC11 Antibody [KO Validated] (CAB19666)")
- SKU:
- CAB19666
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
![Anti-TTC11 Antibody [KO Validated] (CAB19666)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/55986/61168/anti-ttc11-antibody-ko-validated-cab19666__81337__17498.1706533728.jpg?c=1&imbypass=on "Anti-TTC11 Antibody [KO Validated] (CAB19666)")
Description
| Antibody Name: | Anti-TTC11 Antibody [KO Validated] |
| Antibody SKU: | CAB19666 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TTC11. |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Raji, MCF7, Mouse kidney |
| Immunogen: | A synthesized peptide derived from human TTC11. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 51024 |
| Uniprot: | Q9Y3D6 |
| Cellular Location: | Mitochondrion outer membrane, Peroxisome membrane, Single-pass membrane protein |
| Calculated MW: | 15kDa |
| Observed MW: | 17KDa |
![Anti-TTC11 Antibody [KO Validated] (CAB19666)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/i/818/A19666_1__26948.jpg) | Western blot analysis of extracts from normal (control) and TTC11 knockout (KO) HeLa cells, using TTC11 antibody (CAB19666) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
![Anti-TTC11 Antibody [KO Validated] (CAB19666)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/d/074/A19666_2__82957.jpg) | Western blot analysis of extracts of various cell lines, using TTC11 antibody (CAB19666) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
![Anti-TTC11 Antibody [KO Validated] (CAB19666)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/p/444/A19666_3__88101.jpg) | Immunohistochemistry of paraffin-embedded rat brain using TTC11 antibody (CAB19666) at dilution of 1:100 (40x lens). |
![Anti-TTC11 Antibody [KO Validated] (CAB19666)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/e/704/A19666_4__61551.jpg) | Immunohistochemistry of paraffin-embedded human lung cancer using TTC11 antibody (CAB19666) at dilution of 1:100 (40x lens). |
![Anti-TTC11 Antibody [KO Validated] (CAB19666)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/b/590/A19666_5__83598.jpg) | Immunohistochemistry of paraffin-embedded mouse kidney using TTC11 antibody (CAB19666) at dilution of 1:100 (40x lens). |
| Synonyms: | CGI-135, TTC11, FIS1, TTC11 / FIS1, fission |
| Background: | The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to mitochondrial outer membrane; integral to peroxisomal membrane; membrane; mitochondrion; peroxisome; protein complex Molecular Function:protein binding; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; mitochondrion degradation; peroxisome fission; positive regulation of caspase activity; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria |
| NCBI Summary: | The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9Y3D6 |
| NCBI GenInfo Identifier: | 33112470 |
| NCBI Gene ID: | 51024 |
| NCBI Accession: | Q9Y3D6.2 |
| UniProt Secondary Accession: | Q9Y3D6,Q9BTP3, |
| UniProt Related Accession: | Q9Y3D6 |
| Molecular Weight: | 16,938 Da |
| NCBI Full Name: | Mitochondrial fission 1 protein |
| NCBI Synonym Full Names: | fission, mitochondrial 1 |
| NCBI Official Symbol: | FIS1 |
| NCBI Official Synonym Symbols: | TTC11; CGI-135 |
| NCBI Protein Information: | mitochondrial fission 1 protein |
| UniProt Protein Name: | Mitochondrial fission 1 protein |
| UniProt Synonym Protein Names: | FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11 |
| Protein Family: | Mitochondria fission 1 protein |
| UniProt Gene Name: | FIS1 |
| UniProt Entry Name: | FIS1_HUMAN |
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