Cell Biology Antibodies 15

Topors Rabbit Polyclonal Antibody (CAB18526)

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SKU:
CAB18526
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse, Rat
Synonyms:
LUN, TP53BPL, p53BP3/LUN, Topors
Research Use:
Cell Biology
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Description

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Topors Antibody (CAB18526)

The Topors Antibody (CAB18526) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TOPORS protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in cancer biology and DNA repair mechanisms.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.

Product Name:Topors Antibody
SKU:CAB18526
Size:20μL, 100μL
Reactivity:Mouse, Rat
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:PDSK CPIC LDRF DNVS YLDR CLHK FCFR CVQE WSKN KAEC PLCK QPFD SIFH SVRA EDDF KEYV LRPS YNGS FTNP EVRR FRYR TTMT RERS ASLY SPSS T
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:LUN, TP53BPL, p53BP3/LUN, Topors
Positive Sample:Mouse liver, Mouse lung, Mouse kideny, Rat kidney
Cellular Localization:Centriole, Ciliary Basal Body, Gamma-Tubulin Complex, Nuclear Speck, Nucleoplasm, Nucleus, Pml Body, Spindle Pole.
Calculated MW:117kDa
Observed MW:119kDa

Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription, DNA-templated; and regulation of cell population proliferation. Located in ciliary basal body; nucleus; and photoreceptor connecting cilium. Is expressed in skin. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase).

Purification MethodAffinity purification
Gene ID106021
RRIDAB_2862290
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Topors Rabbit pAb (CAB18526) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.
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