Cell Biology Antibodies 8
Anti-TMPRSS2 Antibody (CAB1979)
(No reviews yet)
Write a Review
- SKU:
- CAB1979
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TMPRSS2 Antibody |
| Antibody SKU: | CAB1979 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-400 of human TMPRSS2 (NP_001128571.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HT-29, PC-3, Mouse kidney, Mouse stomach, Rat large intestine, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-400 of human TMPRSS2 (NP_001128571.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLLW KFMG SKCS NSGI ECDS SGTC INPS NWCD GVSH CPGG EDEN RCVR LYGP NFIL QVYS SQRK SWHP VCQD DWNE NYGR AACR DMGY KNNF YSSQ GIVD DSGS TSFM KLNT SAGN VDIY KKLY HSDA CSSK AVVS LRCI ACGV NLNS SRQS RIVG GESA LPGA WPWQ VSLH VQNV HVCG GSII TPEW IVTA AHCV EKPL NNPW HWTA FAGI LRQS FMFY GAGY QVEK VISH PNYD SKTK NNDI ALMK LQKP LTFN DLVK P |
| Gene ID: | 7113 |
| Uniprot: | O15393 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 53kDa/57kDa |
| Observed MW: | 70KDa/54KDa/32KDa |
| Synonyms: | TMPRSS2, PP9284, PRSS10 |
| Background: | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TMPRSS2: a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Protein Details: | Protein type:EC 3.4.21.-; Protease; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; serine-type peptidase activity Biological Process: positive regulation of virion penetration into host cell; protein autoprocessing; proteolysis |
| NCBI Summary: | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | O15393 |
| NCBI GenInfo Identifier: | 115502469 |
| NCBI Gene ID: | 7113 |
| NCBI Accession: | O15393.3 |
| UniProt Secondary Accession: | O15393,Q6GTK7, Q9BXX1, A8K6Z8, B2R8E5, B7Z459, D3DSJ2 F8WES1, |
| UniProt Related Accession: | O15393 |
| Molecular Weight: | 57,690 Da |
| NCBI Full Name: | Transmembrane protease serine 2 |
| NCBI Synonym Full Names: | transmembrane protease, serine 2 |
| NCBI Official Symbol: | TMPRSS2 |
| NCBI Official Synonym Symbols: | PP9284; PRSS10 |
| NCBI Protein Information: | transmembrane protease serine 2 |
| UniProt Protein Name: | Transmembrane protease serine 2 |
| UniProt Synonym Protein Names: | Serine protease 10 |
| Protein Family: | Transmembrane protease serine |
| UniProt Gene Name: | TMPRSS2 |
| UniProt Entry Name: | TMPS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TMPRSS2 antibody (CAB1979) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Western blot analysis of extracts of various cell lines, using TMPRSS2 antibody (CAB1979) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using TMPRSS2 Rabbit pAb (CAB1979) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using TMPRSS2 Rabbit pAb (CAB1979) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using TMPRSS2 Rabbit pAb (CAB1979) at dilution of 1:50 (40x lens). |
View AllClose
Related Products
Anti-VPS11 Antibody (CAB19798)
OverviewProduct Name:VPS11 Rabbit mAbProduct Code:CAB19798Size:20uL, 50uL, 100uLSynonyms:END1, HLD12, PEP5, RNF108, hVPS11
Anti-Renalase Antibody (CAB19797)
OverviewProduct Name:Renalase Rabbit mAbProduct Code:CAB19797Size:20uL, 50uL, 100uLSynonyms:C10orf59, RENALASEApplicat
Anti-Sec61A Antibody (CAB19795)
OverviewProduct Name:Sec61A Rabbit mAbProduct Code:CAB19795Size:20uL, 50uL, 100uLApplications:WBReactivity:Hu
Anti-TAX1BP3 Antibody (CAB19793)
OverviewProduct Name:TAX1BP3 Rabbit mAbProduct Code:CAB19793Size:20uL, 50uL, 100uLSynonyms:TIP-1, TIP1Applications:
Anti-CDC40 Antibody (CAB19794)
OverviewProduct Name:CDC40 Rabbit mAbProduct Code:CAB19794Size:20uL, 50uL, 100uLSynonyms:EHB3, PRP17, PRPF17Applicatio
Anti-ATAD2 Antibody (CAB19792)
OverviewProduct Name:ATAD2 Rabbit mAbProduct Code:CAB19792Size:20uL, 50uL, 100uLSynonyms:ANCCA, CT137, PRO2000Applicat
Anti-GOLPH4 Antibody (CAB19790)
OverviewProduct Name:GOLPH4 Rabbit mAbProduct Code:CAB19790Size:20uL, 50uL, 100uLSynonyms:GIMPC, GOLPH4, GPP130, P138A
