Epigenetics & Nuclear Signaling Antibodies 1
Anti-TLE1 Antibody (CAB13360)
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- SKU:
- CAB13360
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TLE1 Antibody |
| Antibody SKU: | CAB13360 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 256-355 of human TLE1 (NP_005068.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 256-355 of human TLE1 (NP_005068.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DPSS PRAS PAHS PREN GIDK NRLL KKDA SSSP ASTA SSAS STSL KSKE MSLH EKAS TPVL KSST PTPR SDMP TPGT SATP GLRP GLGK PPAI DPLV NQAA |
| Gene ID: | 7088 |
| Uniprot: | Q04724 |
| Cellular Location: | Nucleus |
| Calculated MW: | 83kDa |
| Observed MW: | 83kDa |
| Synonyms: | TLE1, ESG, ESG1, GRG1 |
| Background: |
| UniProt Protein Function: | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
| UniProt Code: | Q04724 |
| NCBI GenInfo Identifier: | 29840816 |
| NCBI Gene ID: | 7088 |
| NCBI Accession: | Q04724.2 |
| UniProt Secondary Accession: | Q04724,Q5T3G4, Q969V9, A8K495, |
| UniProt Related Accession: | Q04724 |
| Molecular Weight: | 83,201 Da |
| NCBI Full Name: | Transducin-like enhancer protein 1 |
| NCBI Synonym Full Names: | transducin like enhancer of split 1 |
| NCBI Official Symbol: | TLE1 |
| NCBI Official Synonym Symbols: | ESG; ESG1; GRG1 |
| NCBI Protein Information: | transducin-like enhancer protein 1 |
| UniProt Protein Name: | Transducin-like enhancer protein 1 |
| UniProt Synonym Protein Names: | E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1 |
| Protein Family: | Transducin-like enhancer protein |
| UniProt Gene Name: | TLE1 |
| UniProt Entry Name: | TLE1_HUMAN |
 | Western blot analysis of extracts of Mouse liver, using TLE1 Rabbit pAb (CAB13360) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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