The TIN2/TINF2 Monoclonal Antibody (CAB9750) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody is raised in rabbits and specifically targets the TIN2/TINF2 protein in human samples, making it ideal for use in various research applications, including Western blotting.Telomeres are essential for protecting the ends of chromosomes and maintaining genomic stability. Dysregulation of telomere length and maintenance is linked to various diseases, including cancer, aging, and genetic disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
TIN2/TINF2 Monoclonal Antibody
SKU:
CAB9750
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1732
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
TIN2, DKCA3, TIN2/TINF2
Positive Sample:
Hep G2, A549, Mouse testis, Mouse thymus, Rat lung, Rat testis
Cellular Localization:
Chromosome, Nucleus, Nucleus Matrix, Telomere.
Calculated MW:
50kDa
Observed MW:
45kDa
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.
Purification Method
Affinity purification
Gene ID
26277
RRID
AB_2863771
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using TIN2/TINF2 Rabbit mAb (CAB9750) at 1:1000 dilution incubated overnight at 4°C Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10 s.
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