Metabolism Antibodies 3

TAX1BP3 Rabbit Polyclonal Antibody (CAB8750)

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SKU:
CAB8750
Product Type:
Antibody
Applications:
WB
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse
Synonyms:
TIP1, TIP-1, TAX1BP3
Research Use:
Metabolism
Frequently bought together:

Description

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TAX1BP3 Antibody (CAB8750)

The TAX1BP3 Antibody (CAB8750) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.TAX1BP3 is a critical regulator of autophagy, a process essential for maintaining cellular homeostasis by removing damaged organelles and proteins. Dysregulation of autophagy has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting the importance of studying proteins like TAX1BP3.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:TAX1BP3 Antibody
SKU:CAB8750
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MSYI PGQP VTAV VQRV EIHK LRQG ENLI LGFS IGGG IDQD PSQN PFSE DKTD KGIY VTRV SEGG PAEI AGLQ IGDK IMQV NGWD MTMV THDQ ARKR LTKR SEEV VRLL VTRQ SLQK AVQQ SMLS
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:TIP1, TIP-1, TAX1BP3
Positive Sample:293T, Mouse kidney
Cellular Localization:Cell Membrane, Cytoplasm, Cytoplasmic Side, Nucleus, Peripheral Membrane Protein.
Calculated MW:14kDa
Observed MW:14kDa

This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Purification MethodAffinity purification
Gene ID30851
RRIDAB_2772528
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using TAX1BP3 Rabbit pAb (CAB8750) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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