Cell Biology Antibodies 10

SPINT2 Rabbit Polyclonal Antibody (CAB6749)

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SKU:
CAB6749
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Synonyms:
PB, Kop, HAI2, DIAR3, HAI-2, SPINT2
Research Use:
Cell Biology
Frequently bought together:

Description

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SPINT2 Antibody (CAB6749)

The SPINT2 Antibody (CAB6749) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the SPINT2 protein, allowing for precise detection and analysis in various cell types.SPINT2, also known as hepatocyte growth factor activator inhibitor 2 (HAI-2), has been implicated in cancer progression, tissue remodeling, and inflammation. Its ability to modulate protease activity makes it a promising target for research on cancer metastasis and tumor microenvironment dynamics.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:SPINT2 Antibody
SKU:CAB6749
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:ADRE RSIH DFCL VSKV VGRC RASM PRWW YNVT DGSC QLFV YGGC DGNS NNYL TKEE CLKK CATV TENA TGDL ATSR NAAD SSVP SAPR RQDS EDHS SDMF NYEE YCTA NAVT GPCR ASFP RWYF DVER NSCN NFIY GGCR GNKN SYRS EEAC MLRC FRQQ ENPP LPLG SK
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:100
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PB, Kop, HAI2, DIAR3, HAI-2, SPINT2
Positive Sample:MCF7
Cellular Localization:Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:28kDa
Observed MW:34kDa

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID10653
RRIDAB_2767333
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from MCF-7 cells, using SPINT2 Rabbit pAb (CAB6749) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageImmunofluorescence analysis of HeLa cells using SPINT2 Rabbit pAb (CAB6749). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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