Developmental Biology
Anti-SFRP2 Antibody (CAB12959)
- SKU:
- CAB12959
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-SFRP2 Antibody |
| Antibody SKU: | CAB12959 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 141-295 of human SFRP2 (NP_003004.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 141-295 of human SFRP2 (NP_003004.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ECDR FPQD NDLC IPLA SSDH LLPA TEEA PKVC EACK NKND DDND IMET LCKN DFAL KIKV KEIT YINR DTKI ILET KSKT IYKL NGVS ERDL KKSV LWLK DSLQ CTCE EMND INAP YLVM GQKQ GGEL VITS VKRW QKGQ REFK RISR SIRK LQC |
| Gene ID: | 6423 |
| Uniprot: | Q96HF1 |
| Cellular Location: | Secreted |
| Calculated MW: | 33kDa |
| Observed MW: | 33kDa |
| Synonyms: | SFRP2, FRP-2, SARP1, SDF-5 |
| Background: | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. |
| UniProt Protein Function: | SFRP2: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Belongs to the secreted frizzled-related protein (sFRP) family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: extracellular matrix; extracellular space; integral to membrane Molecular Function:G-protein coupled receptor activity; integrin binding; Wnt-protein binding; Wnt receptor activity; fibronectin binding; receptor agonist activity Biological Process: convergent extension involved in axis elongation; collagen fibril organization; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; negative regulation of caspase activity; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; cell-cell signaling; negative regulation of mesodermal cell fate specification; positive regulation of cell proliferation; negative regulation of cell migration; response to nutrient; negative regulation of epithelial cell proliferation; response to drug; negative regulation of JNK activity; negative regulation of peptidyl-tyrosine phosphorylation; male gonad development; positive regulation of cell adhesion mediated by integrin; digestive tract morphogenesis; chondrocyte development; positive regulation of peptidyl-serine phosphorylation; positive regulation of cell growth; patterning of blood vessels; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; neural tube closure; cellular response to extracellular stimulus; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96HF1 |
| NCBI GenInfo Identifier: | 61216828 |
| NCBI Gene ID: | 6423 |
| NCBI Accession: | Q96HF1.2 |
| UniProt Secondary Accession: | Q96HF1,O14778, Q9HAP5, B3KQR2, |
| UniProt Related Accession: | Q96HF1 |
| Molecular Weight: | 295 |
| NCBI Full Name: | Secreted frizzled-related protein 2 |
| NCBI Synonym Full Names: | secreted frizzled-related protein 2 |
| NCBI Official Symbol: | SFRP2 |
| NCBI Official Synonym Symbols: | FRP-2; SARP1; SDF-5 |
| NCBI Protein Information: | secreted frizzled-related protein 2; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
| UniProt Protein Name: | Secreted frizzled-related protein 2 |
| UniProt Synonym Protein Names: | Secreted apoptosis-related protein 1; SARP-1 |
| Protein Family: | Secreted frizzled-related protein |
| UniProt Gene Name: | SFRP2 |
| UniProt Entry Name: | SFRP2_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using SFRP2 antibody (CAB12959) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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