Immunology Antibodies 1
Anti-SERPINA3 Antibody (CAB1021)
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- SKU:
- CAB1021
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-SERPINA3 Antibody |
| Antibody SKU: | CAB1021 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-423 of human SERPINA3 (NP_001076.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse testis, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-423 of human SERPINA3 (NP_001076.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HPNS PLDE ENLT QENQ DRGT HVDL GLAS ANVD FAFS LYKQ LVLK APDK NVIF SPLS ISTA LAFL SLGA HNTT LTEI LKGL KFNL TETS EAEI HQSF QHLL RTLN QSSD ELQL SMGN AMFV KEQL SLLD RFTE DAKR LYGS EAFA TDFQ DSAA AKKL INDY VKNG TRGK ITDL IKDL DSQT MMVL VNYI FFKA KWEM PFDP QDTH QSRF YLSK KKWV MVPM MSLH HLTI PYFR DEEL SCTV VELK YTGN ASAL FILP DQDK MEEV EAML LPET LKRW RDSL EFRE IGEL YLPK FSIS RDYN LNDI LLQL GIEE AFTS KADL SGIT GARN LAVS QVVH KAVL DVFE EGTE ASAA TAVK ITLL SALV ETRT IVRF NRPF LMII VPTD TQNI FFMS KVTN PKQA |
| Gene ID: | 12 |
| Uniprot: | P01011 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa/24kDa/47kDa |
| Observed MW: | 48kDa |
| Synonyms: | SERPINA3, AACT, ACT, GIG24, GIG25 |
| Background: | The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. |
| UniProt Protein Function: | SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 14q32.1 Cellular Component: extracellular space; extracellular region; intracellular; nucleus Molecular Function:serine-type endopeptidase inhibitor activity; protein binding; DNA binding Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01011 |
| NCBI GenInfo Identifier: | 112874 |
| NCBI Gene ID: | 12 |
| NCBI Accession: | P01011.2 |
| UniProt Related Accession: | P01011 |
| Molecular Weight: | |
| NCBI Full Name: | Alpha-1-antichymotrypsin |
| NCBI Synonym Full Names: | serpin family A member 3 |
| NCBI Official Symbol: | SERPINA3 |
| NCBI Official Synonym Symbols: | ACT; AACT; GIG24; GIG25 |
| NCBI Protein Information: | alpha-1-antichymotrypsin |
| UniProt Protein Name: | Alpha-1-antichymotrypsin |
| UniProt Synonym Protein Names: | Cell growth-inhibiting gene 24/25 protein; Serpin A3Alpha-1-antichymotrypsin His-Pro-less |
| Protein Family: | Agmatine coumaroyltransferase |
| UniProt Gene Name: | SERPINA3 |
| UniProt Entry Name: | AACT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINA3 antibody (CAB1021) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using SERPINA3 antibody (CAB1021) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using SERPINA3 antibody (CAB1021) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using SERPINA3 antibody (CAB1021). Blue: DAPI for nuclear staining. |
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