Signal Transduction Antibodies 1

Anti-SCN2A Antibody (CAB10574)

(No reviews yet) Write a Review
SKU:
CAB10574
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SCN2A Antibody
Antibody SKU:CAB10574
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 275-401 of human SCN2A (NP_001035232.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:U-87MG, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 275-401 of human SCN2A (NP_001035232.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RNKC LQWP PDNS SFEI NITS FFNN SLDG NGTT FNRT VSIF NWDE YIED KSHF YFLE GQND ALLC GNSS DAGQ CPEG YICV KAGR NPNY GYTS FDTF SWAF LSLF RLMT QDFW ENLY QLTL RAAG KTY
Gene ID:6326
Uniprot:Q99250
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:227kDa
Observed MW:250kDa
Synonyms:SCN2A, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2
Background:Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:SCN2A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Defects in SCN2A are the cause of seizures, benign familial infantile type 3 (BFIS3). An autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae. Defects in SCN2A are the cause of epileptic encephalopathy early infantile type 11 (EIEE11). EIEE11 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: axon; integral to plasma membrane; intrinsic to plasma membrane

Molecular Function:voltage-gated sodium channel activity

Biological Process: generation of action potential; myelination; sodium ion transport

Disease: Epileptic Encephalopathy, Early Infantile, 11; Seizures, Benign Familial Infantile, 3

NCBI Summary:Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
UniProt Code:Q99250
NCBI GenInfo Identifier:25014053
NCBI Gene ID:6326
NCBI Accession:Q99250.3
UniProt Secondary Accession:Q99250,Q14472, Q53T77, Q9BZC9, Q9BZD0, A6NC14, A6NIQ5
UniProt Related Accession:Q99250
Molecular Weight:228kDa
NCBI Full Name:Sodium channel protein type 2 subunit alpha
NCBI Synonym Full Names:sodium voltage-gated channel alpha subunit 2
NCBI Official Symbol:SCN2A  
NCBI Official Synonym Symbols:HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2  
NCBI Protein Information:sodium channel protein type 2 subunit alpha
UniProt Protein Name:Sodium channel protein type 2 subunit alpha
UniProt Synonym Protein Names:HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2
Protein Family:Sodium channel protein
UniProt Gene Name:SCN2A  
Anti-SCN2A Antibody (CAB10574)Western blot analysis of extracts of various cell lines, using SCN2A antibody (CAB10574) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
View AllClose

0 Reviews

View AllClose

Related Products