Epigenetics & Nuclear Signaling Antibodies 1

SAP130 Rabbit Polyclonal Antibody (CAB13897)

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SKU:
CAB13897
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Synonyms:
SAP130
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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SAP130 Antibody (CAB13897)

The SAP130 Antibody (CAB13897) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By targeting the SAP130 protein, researchers can effectively detect and analyze its expression in different cell types, providing insights into its role in biological pathways.SAP130 is a critical component of the splicing factor SF3b complex, which is involved in pre-mRNA splicing and spliceosome assembly. Dysregulation of SAP130 has been linked to various diseases, including cancer and neurodevelopmental disorders, highlighting its importance in cellular function.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse samples.

Product Name:SAP130 Antibody
SKU:CAB13897
Size:20μL, 100μL
Reactivity:Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LSMP TSDL PPGA SPRK KPRK QQHV ISTE EGDM METN STDD EKST AKSL LVKA EKRK SPPK EYID EEGV RYVP VRPR PPIT LLRH YRNP WKAA YHHF QRYS DVRV KEEK KAML QEIA NQKG VSCR AQGW KVHL CAAQ LLQL TNLE HDVY ERLT NLQE GIIP KKKA ATDD DLHR INEL IQGN MQRC KLVM DQIS EARD SMLK VLDH KDRV LKLL NKNG TVKK VSKL KRKE KV
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:SAP130
Positive Sample:Mouse brain
Cellular Localization:Nucleus.
Calculated MW:110kDa
Observed MW:150kDa

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).

Purification MethodAffinity purification
Gene ID79595
RRIDAB_2760751
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from mouse brain, using SAP130 Rabbit pAb (CAB13897) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
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