| UniProt Protein Function: | RPA1: Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing. Heterotrimer composed of RPA1, RPA2 and RPA3 (canonical replication protein A complex). Component of the alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside exclusively on the RPA1 subunit. Interacts with RIPK1 and XPA. Interacts with RPA4. Interacts with the polymerase alpha subunit POLA1/p180; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp. Interact with RAD51 and SENP6 to regulate DNA repair. Interacts with HELB; this interaction promotes HELB recruitement to chromatin following DNA damage. Belongs to the replication factor A protein 1 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: male germ cell nucleus; nucleoplasm; lateral element; PML body; DNA replication factor A complex; nucleus Molecular Function:protein binding; metal ion binding; damaged DNA binding; chromatin binding; single-stranded DNA binding Biological Process: meiosis; mismatch repair; in utero embryonic development; DNA strand elongation during DNA replication; DNA repair; double-strand break repair via homologous recombination; DNA recombination; telomere maintenance via semi-conservative replication; DNA recombinase assembly; homeostasis of number of cells within a tissue; base-excision repair; nucleotide-excision repair; double-strand break repair; transcription-coupled nucleotide-excision repair; positive regulation of cell proliferation; telomere maintenance via recombination; hemopoiesis; nucleotide-excision repair, DNA damage removal; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; DNA replication; DNA-dependent DNA replication; telomere maintenance; G1/S transition of mitotic cell cycle |
| UniProt Code: | P27694 |
| NCBI GenInfo Identifier: | 1350579 |
| NCBI Gene ID: | 6117 |
| NCBI Accession: | P27694.2 |
| UniProt Secondary Accession: | P27694,Q59ES9, A8K0Y9, |
| UniProt Related Accession: | P27694 |
| Molecular Weight: | 616 |
| NCBI Full Name: | Replication protein A 70 kDa DNA-binding subunit |
| NCBI Synonym Full Names: | replication protein A1, 70kDa |
| NCBI Official Symbol: | RPA1 |
| NCBI Official Synonym Symbols: | HSSB; RF-A; RP-A; REPA1; RPA70; MST075 |
| NCBI Protein Information: | replication protein A 70 kDa DNA-binding subunit; MSTP075; RP-A p70; RF-A protein 1; replication factor A protein 1; single-stranded DNA-binding protein |
| UniProt Protein Name: | Replication protein A 70 kDa DNA-binding subunit |
| UniProt Synonym Protein Names: | Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding proteinReplication protein A 70 kDa DNA-binding subunit, N-terminally processed |
| Protein Family: | Replication factor |
| UniProt Gene Name: | RPA1 |
| UniProt Entry Name: | RFA1_HUMAN |
