Metabolism Antibodies 2
Anti-ROR1 Antibody (CAB3315)
- SKU:
- CAB3315
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ROR1 Antibody |
| Antibody SKU: | CAB3315 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human ROR1 (NP_005003.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, 293T, HT-29, SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human ROR1 (NP_005003.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QETE LSVS AELV PTSS WNIS SELN KDSY LTLD EPMN NITT SLGQ TAEL HCKV SGNP PPTI RWFK NDAP VVQE PRRL SFRS TIYG SRLR IRNL DTTD TGYF QCVA TNGK EVVS STGV LFVK FGPP PTAS PGYS DEYE EDGF CQPY RGIA CARF IGNR TVYM ESLH MQGE IEN |
| Gene ID: | 4919 |
| Uniprot: | Q01973 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 42kDa/43kDa/104kDa |
| Observed MW: | 120kDa |
| Synonyms: | ROR1, NTRKR1, dJ537F10.1 |
| Background: | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Ror family Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex Molecular Function:Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q01973 |
| NCBI GenInfo Identifier: | 118572711 |
| NCBI Gene ID: | 4919 |
| NCBI Accession: | Q01973.2 |
| UniProt Secondary Accession: | Q01973,Q5VVX6, Q66K77, Q92776, |
| UniProt Related Accession: | Q01973 |
| Molecular Weight: | 937 |
| NCBI Full Name: | Tyrosine-protein kinase transmembrane receptor ROR1 |
| NCBI Synonym Full Names: | receptor tyrosine kinase-like orphan receptor 1 |
| NCBI Official Symbol: | ROR1 |
| NCBI Official Synonym Symbols: | NTRKR1; dJ537F10.1 |
| NCBI Protein Information: | tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1 |
| UniProt Protein Name: | Tyrosine-protein kinase transmembrane receptor ROR1 |
| UniProt Synonym Protein Names: | Neurotrophic tyrosine kinase, receptor-related 1 |
| Protein Family: | Inactive tyrosine-protein kinase transmembrane receptor |
| UniProt Gene Name: | ROR1 |
| UniProt Entry Name: | ROR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ROR1 antibody (CAB3315) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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