Epigenetics & Nuclear Signaling Antibodies 5
Anti-Reptin / RUVBL2 Antibody (CAB4227)
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- SKU:
- CAB4227
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Reptin / RUVBL2 Antibody |
| Antibody SKU: | CAB4227 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Reptin / RUVBL2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, Mouse testis, Mouse thymus, Rat testis |
| Immunogen: | A synthesized peptide derived from human Reptin / RUVBL2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10856 |
| Uniprot: | Q9Y230 |
| Cellular Location: | |
| Calculated MW: | 48kDa |
| Observed MW: | 50KDa |
| Synonyms: | CGI-46, ECP-51, ECP51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B |
| Background: | This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | RUVBL2: Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Forms homohexameric rings (Probable). Can form a dodecamer with RUVBL1 made of two stacked hexameric rings; however, even though RUVBL1 and RUVBL2 are present in equimolar ratio, the oligomeric status of each hexamer is not known. Oligomerization may regulate binding to nucleic acids and conversely, binding to nucleic acids may affect the dodecameric assembly. Interacts with the transcriptional activation domain of MYC. Interacts With ATF2. Component of the RNA polymerase II holoenzyme complex. May also act to bridge the LEF1/TCF1-CTNNB1 complex and TBP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. RUVBL2 interacts with EP400. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with NPAT. Component of the chromatin- remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C- terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with IGHMBP2. Interacts with TELO2. Ubiquitously expressed. Highly expressed in testis and thymus. Belongs to the RuvB family. |
| UniProt Protein Details: | Protein type:EC 3.6.4.12; Helicase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; membrane; cytoplasm; intracellular; nucleus; ribonucleoprotein complex Molecular Function:ATP-dependent DNA helicase activity; identical protein binding; protein binding; DNA helicase activity; chromatin DNA binding; ATP-dependent 5'-3' DNA helicase activity; unfolded protein binding; ATPase activity; damaged DNA binding; ATP binding Biological Process: chromatin remodeling; establishment and/or maintenance of chromatin architecture; protein folding; transcription, DNA-dependent; regulation of growth; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; DNA repair; DNA duplex unwinding; DNA recombination |
| NCBI Summary: | This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y230 |
| NCBI GenInfo Identifier: | 28201890 |
| NCBI Gene ID: | 10856 |
| NCBI Accession: | Q9Y230.3 |
| UniProt Secondary Accession: | Q9Y230,Q6FIB9, Q6PK27, Q9Y361, B3KQ59, E7ETE5, |
| UniProt Related Accession: | Q9Y230 |
| Molecular Weight: | 463 |
| NCBI Full Name: | RuvB-like 2 |
| NCBI Synonym Full Names: | RuvB-like AAA ATPase 2 |
| NCBI Official Symbol: | RUVBL2 |
| NCBI Official Synonym Symbols: | RVB2; TIH2; ECP51; TIP48; CGI-46; INO80J; REPTIN; TIP49B |
| NCBI Protein Information: | ruvB-like 2; ECP-51; TAP54-beta; reptin52 protein; repressing pontin 52; INO80 complex subunit J; RuvB (E coli homolog)-like 2; 48 kDa TBP-interacting protein; TIP60-associated protein 54-beta; 51 kDa erythrocyte cytosolic protein; erythrocyte cytosolic protein, 51-KD; 48 kDa TATA box-binding protein-interacting protein |
| UniProt Protein Name: | RuvB-like 2 |
| UniProt Synonym Protein Names: | 48 kDa TATA box-binding protein-interacting protein; 48 kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; ECP-51; INO80 complex subunit J; Repressing pontin 52; Reptin 52; TIP49b; TIP60-associated protein 54-beta; TAP54-beta |
| Protein Family: | RuvB |
| UniProt Gene Name: | RUVBL2 |
| UniProt Entry Name: | RUVB2_HUMAN |
 | Western blot - Reptin / RUVBL2 Rabbit mAb (CAB4227) |
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