Cell Biology Antibodies 17

Anti-RanGAP1 Antibody (CAB8758)

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SKU:
CAB8758
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RanGAP1 Antibody
Antibody SKU:CAB8758
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RanGAP1
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SKOV3, PC-3, C6, SH-SY5Y, NIH/3T3, Mouse liver, Mouse testis, Mouse brain, Rat testis
Immunogen:A synthesized peptide derived from human RanGAP1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5905
Uniprot:P46060
Cellular Location:
Calculated MW:64, 90kDa
Observed MW:65KDa/90KDa
Synonyms:Fug1, RANGAP, SD
Background:This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Protein Function:RANGAP1: a cytoplasmic GTPase activator for the Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. Homodimerizes. Forms a tight complex in association with RANBP2 and the ubiquitin-conjugating enzyme E2 (UBC9).
UniProt Protein Details:

Protein type:GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 22q13

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; kinetochore; nuclear envelope; nuclear membrane; nuclear pore

Molecular Function:protein binding

Biological Process: negative regulation of protein export from nucleus; protein sumoylation; sister chromatid cohesion

NCBI Summary:This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:P46060
NCBI GenInfo Identifier:1172922
NCBI Gene ID:5905
NCBI Accession:P46060.1
UniProt Secondary Accession:P46060,Q96JJ2,
UniProt Related Accession:P46060
Molecular Weight:63,542 Da
NCBI Full Name:Ran GTPase-activating protein 1
NCBI Synonym Full Names:Ran GTPase activating protein 1
NCBI Official Symbol:RANGAP1  
NCBI Official Synonym Symbols:SD; Fug1; RANGAP  
NCBI Protein Information:ran GTPase-activating protein 1
UniProt Protein Name:Ran GTPase-activating protein 1
Protein Family:RAN GTPase-activating protein
UniProt Gene Name:RANGAP1  
UniProt Entry Name:RAGP1_HUMAN
Anti-RanGAP1 Antibody (CAB8758)Western blot - RanGAP1 Rabbit mAb (CAB8758)
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