Cell Biology Antibodies 17
Anti-RanGAP1 Antibody (CAB8758)
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- SKU:
- CAB8758
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RanGAP1 Antibody |
| Antibody SKU: | CAB8758 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RanGAP1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, PC-3, C6, SH-SY5Y, NIH/3T3, Mouse liver, Mouse testis, Mouse brain, Rat testis |
| Immunogen: | A synthesized peptide derived from human RanGAP1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5905 |
| Uniprot: | P46060 |
| Cellular Location: | |
| Calculated MW: | 64, 90kDa |
| Observed MW: | 65KDa/90KDa |
| Synonyms: | Fug1, RANGAP, SD |
| Background: | This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Protein Function: | RANGAP1: a cytoplasmic GTPase activator for the Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. Homodimerizes. Forms a tight complex in association with RANBP2 and the ubiquitin-conjugating enzyme E2 (UBC9). |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 22q13 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; kinetochore; nuclear envelope; nuclear membrane; nuclear pore Molecular Function:protein binding Biological Process: negative regulation of protein export from nucleus; protein sumoylation; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P46060 |
| NCBI GenInfo Identifier: | 1172922 |
| NCBI Gene ID: | 5905 |
| NCBI Accession: | P46060.1 |
| UniProt Secondary Accession: | P46060,Q96JJ2, |
| UniProt Related Accession: | P46060 |
| Molecular Weight: | 63,542 Da |
| NCBI Full Name: | Ran GTPase-activating protein 1 |
| NCBI Synonym Full Names: | Ran GTPase activating protein 1 |
| NCBI Official Symbol: | RANGAP1 |
| NCBI Official Synonym Symbols: | SD; Fug1; RANGAP |
| NCBI Protein Information: | ran GTPase-activating protein 1 |
| UniProt Protein Name: | Ran GTPase-activating protein 1 |
| Protein Family: | RAN GTPase-activating protein |
| UniProt Gene Name: | RANGAP1 |
| UniProt Entry Name: | RAGP1_HUMAN |
 | Western blot - RanGAP1 Rabbit mAb (CAB8758) |
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