Epigenetics & Nuclear Signaling Antibodies 5

Anti-Rad18 Antibody (CAB4339)

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SKU:
CAB4339
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-Rad18 Antibody
Antibody SKU:CAB4339
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Rad18
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, A-549, MCF7, K-562, Mouse testis, Mouse brain, Mouse spleen, Rat testis
Immunogen:A synthesized peptide derived from human Rad18
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:56852
Uniprot:Q9NS91
Cellular Location:Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:56kDa
Observed MW:70KDa/90KDa
Synonyms:RNF73
Background:The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
UniProt Protein Function:RAD18: a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.
UniProt Protein Details:

Protein type:DNA repair, damage; EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: XY body; replication fork; nucleus; chromatin

Molecular Function:Y-form DNA binding; protein binding; zinc ion binding; ubiquitin protein ligase binding; damaged DNA binding; polyubiquitin binding; ligase activity

Biological Process: negative regulation of DNA recombination; protein ubiquitination; spermatogenesis; DNA repair; response to UV

NCBI Summary:The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NS91
NCBI GenInfo Identifier:313104165
NCBI Gene ID:56852
NCBI Accession:Q9NS91.2
UniProt Secondary Accession:Q9NS91,Q58F55, Q9NRT6,
UniProt Related Accession:Q9NS91
Molecular Weight:495
NCBI Full Name:E3 ubiquitin-protein ligase RAD18
NCBI Synonym Full Names:RAD18 E3 ubiquitin protein ligase
NCBI Official Symbol:RAD18  
NCBI Official Synonym Symbols:RNF73  
NCBI Protein Information:E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; RAD18 homolog; RING finger protein 73; RAD18, S. cerevisiae, homolog; postreplication repair protein RAD18; postreplication repair protein hRAD18p
UniProt Protein Name:E3 ubiquitin-protein ligase RAD18
UniProt Synonym Protein Names:Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:RAD18  
UniProt Entry Name:RAD18_HUMAN
Anti-Rad18 Antibody (CAB4339)Western blot - Rad18 Rabbit mAb (CAB4339)
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