Autophagy Antibodies

RAB7 Rabbit Polyclonal Antibody (CAB1154)

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SKU:
CAB1154
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy
Reactivity:
Human, Mouse, Rat
Synonyms:
RAB7, CMT2B, PRO2706
Research Use:
Autophagy
Frequently bought together:

Description

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RAB7 Antibody (CAB1154)

The RAB7 Antibody (CAB1154) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity when used with human samples, making it ideal for Western blot applications.Rab7A plays a crucial role in the late endocytic pathway, where it controls the trafficking of cargo proteins to lysosomes for degradation. Dysregulation of Rab7A has been linked to various diseases, including neurodegenerative disorders and cancer.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:RAB7 Antibody
SKU:CAB1154
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:DSWR DEFL IQAS PRDP ENFP FVVL GNKI DLEN RQVA TKRA QAWC YSKN NIPY FETS AKEA INVE QAFQ TIAR NALK QETE VELY NEFP EPIK LDKN DRAK ASAE SCSC
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:RAB7, CMT2B, PRO2706
Positive Sample:K-562
Cellular Localization:Cytoplasmic Side, Cytoplasmic Vesicle, Late Endosome Membrane, Lipid Droplet, Lysosome Membrane, Melanosome Membrane, Peripheral Membrane Protein, Autophagosome Membrane, Phagosome Membrane.
Calculated MW:23kDa
Observed MW:23kDa

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.

Purification MethodAffinity purification
Gene ID7879
RRIDAB_2758598
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from K-562 cells, using RAB7 Rabbit pAb (CAB1154). Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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