KO Validated Antibodies 2

Anti-RAB2A Antibody (CAB19982)[KO Validated]

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SKU:
CAB19982
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RAB2A Antibody [KO Validated]
Antibody SKU:CAB19982
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RAB2A.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant protein of human RAB2A.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5862
Uniprot:P61019
Cellular Location:Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Lipid-anchor, Melanosome
Calculated MW:20kDa/23kDa
Observed MW:22KDa
Anti-RAB2A Antibody [KO Validated] (CAB19982)Western blot analysis of extracts from normal (control) and RAB2A knockout (KO) 293T cells, using RAB2A antibody (CAB19982) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
Synonyms:RAB2A, LHX, RAB2
Background:The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Rab2: Required for protein transport from the endoplasmic reticulum to the Golgi complex. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 8q12.1-q12.2

Cellular Component: cytosol; Golgi apparatus; Golgi membrane; lysosomal membrane; nucleus

Molecular Function:GDP binding; GTP binding; GTPase activity; protein binding

Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis

NCBI Summary:The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:P61019
NCBI GenInfo Identifier:46577636
NCBI Gene ID:5862
NCBI Accession:P61019.1
UniProt Secondary Accession:P61019,P08886, B2R5W8, B4DMQ5,
UniProt Related Accession:P61019
Molecular Weight:24kDa
NCBI Full Name:Ras-related protein Rab-2A
NCBI Synonym Full Names:RAB2A, member RAS oncogene family
NCBI Official Symbol:RAB2A  
NCBI Official Synonym Symbols:LHX; RAB2  
NCBI Protein Information:ras-related protein Rab-2A
UniProt Protein Name:Ras-related protein Rab-2A
Protein Family:Ras-related protein
UniProt Gene Name:RAB2A  
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