PSMA Rabbit Monoclonal Antibody (CAB9547)

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SKU:
CAB9547
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Reactivity:
Human, Rat
Synonyms:
PSM, FGCP, FOLH, GCP2, PSMA, mGCP, GCPII, NAALAD1, PSMA/FOLH1
Research Use:
Cell Biology
Frequently bought together:

Description

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PSMA Monoclonal Antibody (CAB9547)

The PSMA Monoclonal Antibody (CAB9547) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is raised in rabbits and has been validated for use in various applications, including Western blot, immunohistochemistry, and flow cytometry.PSMA/FOLH1 is a cell surface marker that is overexpressed in prostate cancer cells, making it an attractive target for cancer research and therapy development. The antibody binds specifically to PSMA/FOLH1, allowing for the detection and analysis of this protein in different cell types and tissue samples.

This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Human, Rat samples.

Product Name:PSMA Monoclonal Antibody
SKU:CAB9547
Size:20μL, 100μL
Reactivity:Human, Rat
Clone Number:ARC1628
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MWNL LHET DSAV ATAR RPRW LCAG ALVL AGGF FLLG FLFG WFIK SSNE ATNI TPKH NMKA FLDE LKAE NIKK FLYN FTQI PHLA GTEQ NFQL AKQI QSQW KEFG LD
Tested Applications:WB ELISA IF-P
Recommended Dilution:
WB1:500 - 1:1000
IF-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PSM, FGCP, FOLH, GCP2, PSMA, mGCP, GCPII, NAALAD1, PSMA/FOLH1
Positive Sample:LNCaP
Cellular Localization:Cell Surface, Cytoplasm, Extracellular Exosome, Plasma Membrane.
Calculated MW:84kDa
Observed MW:100kDa

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

Purification MethodAffinity purification
Gene ID2346
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from LNCaP cells, using PSMA/FOLH1 Rabbit mAb (CAB9547) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
Product ImageImmunofluorescence analysis of paraffin-embedded rat prostate using PSMA/FOLH1 Rabbit mAb (CAB9547) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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