Cell Death Antibodies 1

Presenilin 1 Rabbit Polyclonal Antibody (CAB2187)

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SKU:
CAB2187
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
AD3, FAD, PS1, PS-1, S182, PSNL1, ACNINV3, Presenilin 1
Research Use:
Cell Death
Frequently bought together:

Description

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Presenilin 1 Antibody (CAB2187)

The Presenilin 1 Antibody (CAB2187) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.Presenilin-1 plays a crucial role in the pathogenesis of Alzheimer's disease, as mutations in this protein are associated with early-onset familial Alzheimer's disease.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Presenilin 1 Antibody
SKU:CAB2187
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:STMV WLVN MAEG DPEA QRRV SKNS KYNA ESTE RESQ DTVA ENDD GGFS EEWE AQRD SHLG PHRS TPES RAAV QELS SSIL AGED PEER GVK
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:AD3, FAD, PS1, PS-1, S182, PSNL1, ACNINV3, Presenilin 1
Positive Sample:U-87MG
Cellular Localization:Cell Membrane, Cell Surface, Endoplasmic Reticulum Membrane, Golgi Apparatus Membrane, Multi-Pass Membrane Protein.
Calculated MW:53kDa
Observed MW:52kDa

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Purification MethodAffinity purification
Gene ID5663
RRIDAB_2764205
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from U-87MG cells, using Presenilin 1 Rabbit pAb (CAB2187) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human liver using Presenilin 1 Rabbit pAb (CAB2187) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunofluorescence analysis of HeLa cells using Presenilin 1 Rabbit pAb (CAB2187) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of L929 cells using Presenilin 1 Rabbit pAb (CAB2187) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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