Cell Biology Antibodies 12
Anti-Progonadoliberin-2 Antibody (CAB8424)
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- SKU:
- CAB8424
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Progonadoliberin-2 Antibody |
| Antibody SKU: | CAB8424 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human GNRH2 (NP_001492.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human GNRH2 (NP_001492.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QHWS HGWY PGGK RALS SAQD PQNA LRPP GRAL DTAA GSPV QTAH GLPS DALA PLDD SMPW EGRT TAQW SLHR KRHL ARTL LTAA REPR PAPP SSNK V |
| Gene ID: | 2797 |
| Uniprot: | O43555 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa |
| Observed MW: | 20kDa |
| Synonyms: | GNRH2, GnRH-II, LH-RHII |
| Background: | This gene encodes a secreted peptide hormone and member of the gonadotropin-releasing hormone (GnRH) family of proteins. The encoded protein regulates reproductive function by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The encoded protein may inhibit endometrial, ovarian, prostate, and breast cancer cell proliferation. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GNRH2: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20p13 Cellular Component: extracellular region Biological Process: signal transduction |
| NCBI Summary: | This gene encodes a secreted peptide hormone and member of the gonadotropin-releasing hormone (GnRH) family of proteins. The encoded protein regulates reproductive function by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The encoded protein may inhibit endometrial, ovarian, prostate, and breast cancer cell proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| UniProt Code: | O43555 |
| NCBI GenInfo Identifier: | 3913735 |
| NCBI Gene ID: | 2797 |
| NCBI Accession: | O43555.1 |
| UniProt Secondary Accession: | O43555,Q14C68, Q14C69, Q9BYN9, Q9BYP0, |
| UniProt Related Accession: | O43555 |
| Molecular Weight: | 12,233 Da |
| NCBI Full Name: | Progonadoliberin-2 |
| NCBI Synonym Full Names: | gonadotropin releasing hormone 2 |
| NCBI Official Symbol: | GNRH2 |
| NCBI Official Synonym Symbols: | GnRH-II; LH-RHII |
| NCBI Protein Information: | progonadoliberin-2 |
| UniProt Protein Name: | Progonadoliberin-2 |
| UniProt Synonym Protein Names: | Progonadoliberin II |
| Protein Family: | Progonadoliberin |
| UniProt Gene Name: | GNRH2 |
| UniProt Entry Name: | GON2_HUMAN |
 | Western blot analysis of extracts of 293T cells, using GNRH2 antibody (CAB8424) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using GNRH2 antibody (CAB8424) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using GNRH2 antibody (CAB8424) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using GNRH2 antibody (CAB8424) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using GNRH2 antibody (CAB8424) at dilution of 1:100 (40x lens). |
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