The Phospho-alpha-Synuclein-S129 Antibody (CABP0450) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, raised in rabbits, specifically targets the phosphorylated form of alpha-synuclein at Serine 129, a key post-translational modification associated with the pathogenesis of Parkinson's disease.Alpha-synuclein is a protein involved in neurotransmitter release and synaptic function, with aberrant aggregation of this protein being a hallmark of Parkinson's disease. Phosphorylation at Serine 129 has been linked to increased toxicity and accumulation of alpha-synuclein aggregates in neurons, leading to neurodegeneration.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Phospho-alpha-Synuclein-S129 Antibody
SKU:
CABP0450
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:
MPSE E
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:500 - 1:2000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Purification Method
Affinity purification
Gene ID
6622
RRID
AB_2771549
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain tissue, using Phospho-α-Synuclein-S129 Rabbit pAb (CABP0450). Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% BSA.
