The PER3 Monoclonal Antibody (CAB2219) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.PER3 is a key player in the circadian rhythm, influencing the timing of sleep and wakefulness as well as other biological processes. Dysregulation of PER3 has been linked to sleep disorders, mood disorders, and other health issues related to disrupted sleep patterns.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
PER3 Monoclonal Antibody
SKU:
CAB2219
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1893
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
GIG13, FASPS3, PER3
Positive Sample:
HeLa, Mouse lung, Mouse kidney, Rat lung
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
132kDa
Observed MW:
132kDa
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method
Affinity purification
Gene ID
8863
RRID
AB_2862977
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using PER3 Rabbit mAb (CAB2219) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
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