Cardiovascular Antibodies

PDCD10 Rabbit Polyclonal Antibody (CAB17094)

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SKU:
CAB17094
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
Reactivity:
Human, Mouse, Rat
Synonyms:
CCM3, TFAR15, PDCD10
Research Use:
Cardiovascular
Frequently bought together:

Description

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PDCD10 Antibody (CAB17094)

The PDCD10 Antibody (CAB17094) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in Western blotting applications.PDCD10 is a crucial player in cell signaling pathways that control programmed cell death and cell proliferation. Dysregulation of PDCD10 has been implicated in various diseases, including cancer and neurological disorders. By targeting PDCD10 with this antibody, researchers can gain insights into the protein's function and potential therapeutic implications.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:PDCD10 Antibody
SKU:CAB17094
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MRMT MEEM KNEA ETTS MVSM PLYA VMYP VFNE LERV NLSA AQTL RAAF IKAE KENP GLTQ DIIM KILE KKSV EVNF TESL LRMA ADDV EEYM IERP EPEF QDLN EKAR ALKQ ILSK IPDE INDR VRFL QTIK DIAS AIKE LLDT VNNV FKKY QYQN RRAL EHQK KEFV KYSK SFSD TLKT YFKD GKAI NVFV SANR LIHQ TNLI LQTF KTVA
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CCM3, TFAR15, PDCD10
Positive Sample:Rat lung, Rat spleen
Cellular Localization:Cell Membrane, Cytoplasm, Cytoplasmic Side, Golgi Apparatus Membrane, Peripheral Membrane Protein.
Calculated MW:25kDa
Observed MW:26kDa

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Purification MethodAffinity purification
Gene ID11235
RRIDAB_2770821
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using PDCD10 Rabbit pAb (CAB17094) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 45s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Rat spleen using PDCD10 Rabbit pAb (CAB17094) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse kidney using PDCD10 Rabbit pAb (CAB17094) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunofluorescence analysis of PC-12 cells using PDCD10 Rabbit pAb (CAB17094) at dilution of 1:200 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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