Cell Biology Antibodies 13

PCDHB4 Rabbit Polyclonal Antibody (CAB17733)

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SKU:
CAB17733
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
PCDH-BETA4, PCDHB4
Research Use:
Cell Biology
Frequently bought together:

Description

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PCDHB4 Antibody (CAB17733)

The PCDHB4 Antibody (CAB17733) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific for detecting PCDHB4 in human samples and has been validated for use in Western blot applications.PCDHB4 is known to play a role in cell-cell adhesion and communication, particularly in the nervous system where it contributes to neuronal development and synaptic plasticity. Studies have also shown its involvement in cancer progression and metastasis, highlighting its potential as a therapeutic target in oncology research.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:PCDHB4 Antibody
SKU:CAB17733
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:EPIR YSVL EETE SGSF VAHL AKDL GLGI GELA SRSA RVLS DDDK QRLQ LDRQ TGDL LLRE KLDR EELC GPIE PCVL HFQV FLEM PVQF FQGE LLIQ DIND HSPI FPER EVLL KILE NSQP GTLF PLLI AEDL DVGS NGLQ KYTI SPNS HFHI LTRN HSEG KKYP DLVQ DKPL DREE QPEF SLTL VALD GGSP PRSG TVMV RILI MDIN DNAP EFVH TPYG VQVL ENSP LDSP IVRV LARD IDAG NFGS VSYG LFQA SDEI KQTF SINE VTGE I
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PCDH-BETA4, PCDHB4
Positive Sample:293T, Raji, Mouse testis, Rat testis
Cellular Localization:Plasma Membrane, Synapse.
Calculated MW:87kDa
Observed MW:87kDa

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Purification MethodAffinity purification
Gene ID56131
RRIDAB_2770809
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using PCDHB4 Rabbit pAb (CAB17733) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
Product ImageImmunofluorescence analysis of L929 cells using PCDHB4 Rabbit pAb (CAB17733) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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