Anti-p38 Antibody

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SKU:
STPA00027
Antibody Type:
Polyclonal
Applications:
WB
Applications:
IHC
Applications:
ICC/IF
Applications:
IP
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Reactivity:
Bovine
Reactivity:
Monkey
Reactivity:
Rabbit
Reactivity:
Pig
Reactivity:
Dog
Reactivity:
Hamster
Reactivity:
Chicken
Reactivity:
Sheep
Reactivity:
Guinea Pig (Cavia porcellus)
Host Species:
Rabbit
  • Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-p38 Polyclonal Antibody (STPA00027). Tissue: Cervical cancer cell line (HeLa). Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-p38 Polyclonal Antibody (STPA00027) at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT.
  • Western blot analysis of Human cancer cell lines showing detection of p38 protein using Rabbit Anti-p38 Polyclonal Antibody (STPA00027). Load: 15 µgprotein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Rabbit Anti-p38 Polyclonal Antibody (STPA00027) at 1:4000 for 2 hours at RT. Secondary Antibody: Donkey Anti-Rabbit IgG: HRP for 1 hour at RT.
  • Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-p38 Polyclonal Antibody (STPA00027). Tissue: Cervical cancer cell line (HeLa). Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-p38 Polyclonal Antibody (STPA00027) at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT.
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Description

p38 Antibody

p38 Antibody is a rabbit polyclonal antibody directed against p38, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and IP. Reported reactivity: Human, Mouse, Rat, Bovine, Monkey, Rabbit, Pig, Dog, Hamster, Chicken, Sheep and Guinea Pig (Cavia porcellus). Purified by Peptide Affinity.

p38 is a member of the mitogen-activated protein kinase (MAPK) family, specifically involved in cellular responses to stress and inflammation. In the nervous system, p38 plays a pivotal role in regulating apoptosis, neuroinflammation, and synaptic plasticity—processes that are frequently dysregulated in neurodegenerative diseases. Upon activation by environmental and cellular stressors such as oxidative damage, cytokines, and UV radiation, p38 translocates to the nucleus where it modulates transcription factors and pro-apoptotic proteins. This leads to the release of cytochrome c, activation of caspase-3, and cleavage of PARP, promoting programmed cell death. In Alzheimer’s, Parkinson’s, and ALS, aberrant p38 signaling contributes to neuronal loss, glial activation, and neurodegenerative phenotypes. As a result, p38 has emerged as a therapeutic target for modulating neuroinflammation and preventing neuronal degeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µl. For research use only; not for diagnostic or therapeutic procedures.

Product Name:p38 Antibody
Product SKU:STPA00027
Size:100 µl
Target:p38
Host Species:Rabbit
Antibody Type:Polyclonal
Research Areas:Cell Signaling, Post-translational Modifications, Phosphorylation, Cancer
Buffer:PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, IHC, ICC/IF, IP
Purification:Peptide Affinity Purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat, Bovine, Monkey, Rabbit, Pig, Dog, Hamster, Chicken, Sheep, Guinea Pig (Cavia porcellus)
Recommended Dilution:WB (1:1000), ICC/IF (1:100), IP (1:250); optimal dilutions for assays should be determined by the user.
Specificity:Detects ~43kDa.
Guarantee:12 months from date of dispatch
Immunogen:A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH
Immunogen Species:Human
Accession Number:NP_001306.1
Gene ID:1432
Swiss-Prot:Q16539
Cellular Localization:Cytoplasm | Nucleus
Alternative Names:CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A
References:1. Pearson G., et al (2001) Endocrine Reviews 22 (2): 153-183. 2. Fan Y., et al (2007) Mol. Cells 23 (1): 30-38. 3. Han J., et al. (1994) Science 265: 808-811. 4. Van L. A., et al. (2004) Faseb J. 18: 1946−1948. 5. Deng et al. (2003) Cell 115: 61-70. 6. Salojin K.V., et al. (2006) J Immunol. 176 (3):1899-907. 7. Medicherla S., et al. (2006) J Pharmacol Exp Ther. 318(1): 99-107.
Note:For research use only.
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