The p16-ARC/ARC16/ARPC5 Monoclonal Antibody (CAB4794) is a high-quality antibody developed for reliable detection and analysis of target proteins. p16 is a key regulator of cell cycle progression, specifically acting as a tumor suppressor by inhibiting the activity of cyclin-dependent kinases. This antibody is raised in rabbits and has been validated for use in Western blot applications, providing researchers with a reliable tool for detecting and analyzing p16 expression in various cell types.The p16 protein is known for its role in cell senescence and the prevention of uncontrolled cell growth, making it a crucial target for studying cancer development and progression.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
p16-ARC/ARC16/ARPC5 Monoclonal Antibody
SKU:
CAB4794
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC0221
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
ARC16, p16-Arc, dJ127C7.3, p16-ARC/ARC16/ARPC5
Positive Sample:
293T, Mouse brain, Mouse thymus, Rat brain, Rat thymus
Cellular Localization:
Cell Projection, Cytoplasm, Cytoskeleton.
Calculated MW:
16kDa
Observed MW:
18kDa
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
Purification Method
Affinity purification
Gene ID
10092
RRID
AB_2863349
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using p16-ARC/ARC16/ARPC5 Rabbit mAb (CAB4794) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 3min.
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