Cell Biology Antibodies 17
Anti-NDUFS3 Antibody (CAB4602)
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- SKU:
- CAB4602
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CI-30
- Research Area:
- Cell Biology
Description
| Product Name: | NDUFS3 Rabbit mAb |
| Product Code: | CAB4602 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CI-30 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NDUFS3 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, A-431, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human NDUFS3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4722 |
| Uniprot: | O75489 |
| Calculated MW: | 30kDa |
| Observed MW: | 28KDa |
| UniProt Protein Function: | NDUFS3: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 30 kDa subunit family. |
| UniProt Protein Details: | Protein type:EC 1.6.5.3; Oxidoreductase; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial Chromosomal Location of Human Ortholog: 11p11.11 Cellular Component: mitochondrial matrix; mitochondrial membrane; mitochondrial respiratory chain complex I; mitochondrion; nucleus Molecular Function:NADH dehydrogenase activity; protein binding Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; negative regulation of cell growth; substantia nigra development Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency |
| NCBI Summary: | This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009] |
| UniProt Code: | O75489 |
| NCBI GenInfo Identifier: | 6166589 |
| NCBI Gene ID: | 4722 |
| NCBI Accession: | O75489.1 |
| UniProt Secondary Accession: | O75489,Q9UNQ8, B2R9J1, B4DFM8, |
| UniProt Related Accession: | O75489 |
| Molecular Weight: | 14,679 Da |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase core subunit S3 |
| NCBI Official Symbol: | NDUFS3 |
| NCBI Official Synonym Symbols: | CI-30 |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| UniProt Synonym Protein Names: | Complex I-30kD; CI-30kD; NADH-ubiquinone oxidoreductase 30 kDa subunit |
| UniProt Gene Name: | NDUFS3 |
| UniProt Entry Name: | NDUS3_HUMAN |
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