UniProt Protein Function: | NDUFB4: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFB4 subunit family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Energy Metabolism - oxidative phosphorylation; EC 1.6.5.3; EC 1.6.99.3; Membrane protein, integral; Oxidoreductase Chromosomal Location of Human Ortholog: 3q13.33 Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion; nuclear membrane; nucleoplasm Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; response to oxidative stress |
NCBI Summary: | This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009] |
UniProt Code: | O95168 |
NCBI GenInfo Identifier: | 6093473 |
NCBI Gene ID: | 4710 |
NCBI Accession: | O95168.3 |
UniProt Secondary Accession: | O95168,B2RUY3, B9EJC7, |
UniProt Related Accession: | O95168 |
Molecular Weight: | 14,026 Da |
NCBI Full Name: | NADH dehydrogenase |
NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase subunit B4 |
NCBI Official Symbol: | NDUFB4 |
NCBI Official Synonym Symbols: | B15; CI-B15 |
NCBI Protein Information: | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 |
UniProt Protein Name: | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 |
UniProt Synonym Protein Names: | Complex I-B15; CI-B15; NADH-ubiquinone oxidoreductase B15 subunit |
Protein Family: | NADH dehydrogenase |
UniProt Gene Name: | NDUFB4 |
UniProt Entry Name: | NDUB4_HUMAN |