Anti-Nav1.7 Antibody [N68/6 (Formerly sold as S68-6)]

Nav1.7 Antibody [N68/6 (Formerly sold as S68-6)]

Nav1.7 Antibody [N68/6 (Formerly sold as S68-6)] is a mouse monoclonal antibody directed against Nav1.7, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and AM. Reported reactivity: Human, Mouse, Rat and Hamster. Supplied as IgG1, purified by Protein G.

Nav1.7 is a voltage-gated sodium channel encoded by the SCN9A gene and is predominantly expressed in peripheral sensory neurons. It plays a pivotal role in pain perception by amplifying subthreshold stimuli and facilitating action potential initiation. Loss-of-function mutations in Nav1.7 result in congenital insensitivity to pain, while gain-of-function mutations are associated with chronic pain syndromes. Importantly, Nav1.7 is not expressed in cardiac or central neurons, making it an attractive target for pain therapeutics with minimal off-target effects. Although primarily studied in nociception, emerging research suggests that peripheral nerve dysfunction and chronic pain may contribute to neurodegenerative disease burden. Nav1.7 inhibitors are under investigation as next-generation analgesics with potential applications in neurodegenerative conditions involving neuropathic pain. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.