Cell Biology Antibodies 6
Anti-NAT1 Antibody (CAB1563)
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- SKU:
- CAB1563
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NAT1 Antibody |
| Antibody SKU: | CAB1563 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human NAT1 (NP_001153646.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | U-937 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human NAT1 (NP_001153646.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDIE AYLE RIGY KKSR NKLD LETL TDIL QHQI RAVP FENL NIHC GDAM DLGL EAIF DQVV RRNR GGWC LQVN HLLY WALT TIGF ETTM LGGY VYST PAKK YSTG MIHL LLQV TIDG RNYI VDAG FGRS YQMW QPLE LISG KDQP QVPC VFRL TEEN GFWY LDQI RREQ YIPN EEFL HSDL LEDS KYRK IYSF TLKP RTIE DFES MNTY LQTS PSSV FTSK SFCS LQTP DGVH CLVG FTLT HRRF NYKD NTDL IEFK TLSE EEIE KVLK NIFN ISLQ RKLV PKHG DRFF TI |
| Gene ID: | 9 |
| Uniprot: | P18440 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 33kDa |
| Observed MW: | 33kDa |
| Synonyms: | NAT1, AAC1, MNAT, NAT-1, NATI |
| Background: | This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NAT1: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Belongs to the arylamine N-acetyltransferase family. |
| UniProt Protein Details: | Protein type:EC 2.3.1.5; Acetyltransferase; Xenobiotic Metabolism - drug metabolism - other enzymes; Secondary Metabolites Metabolism - caffeine Chromosomal Location of Human Ortholog: 8p22 Cellular Component: cytosol Molecular Function:arylamine N-acetyltransferase activity Biological Process: xenobiotic metabolic process |
| NCBI Summary: | This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P18440 |
| NCBI GenInfo Identifier: | 114234 |
| NCBI Gene ID: | 9 |
| NCBI Accession: | P18440.2 |
| UniProt Secondary Accession: | P18440,O15159, O15300, Q546N1, Q96TE9, A8K4E7, |
| UniProt Related Accession: | P18440 |
| Molecular Weight: | 33,899 Da |
| NCBI Full Name: | Arylamine N-acetyltransferase 1 |
| NCBI Synonym Full Names: | N-acetyltransferase 1 (arylamine N-acetyltransferase) |
| NCBI Official Symbol: | NAT1 |
| NCBI Official Synonym Symbols: | AAC1; MNAT; NATI; NAT-1 |
| NCBI Protein Information: | arylamine N-acetyltransferase 1; arylamide acetylase 1; N-acetyltransferase type 1; monomorphic arylamine N-acetyltransferase |
| UniProt Protein Name: | Arylamine N-acetyltransferase 1 |
| UniProt Synonym Protein Names: | Arylamide acetylase 1; Monomorphic arylamine N-acetyltransferase; MNAT; N-acetyltransferase type 1; NAT-1 |
| Protein Family: | Arylamine N-acetyltransferase |
| UniProt Gene Name: | NAT1 |
| UniProt Entry Name: | ARY1_HUMAN |
 | Western blot analysis of extracts of U-937 cells, using NAT1 antibody (CAB1563) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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