UniProt Protein Function: | MRPS30: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q11 Cellular Component: mitochondrial inner membrane; ribosome Molecular Function:structural constituent of ribosome Biological Process: mitochondrial translation; apoptosis; organelle organization and biogenesis |
NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NP92 |
NCBI GenInfo Identifier: | 116242771 |
NCBI Gene ID: | 10884 |
NCBI Accession: | Q9NP92.2 |
UniProt Secondary Accession: | Q9NP92,Q96I91, Q96Q19, Q9H0P8, Q9NSF9, Q9NZ76, |
UniProt Related Accession: | Q9NP92 |
Molecular Weight: | 439 |
NCBI Full Name: | 28S ribosomal protein S30, mitochondrial |
NCBI Synonym Full Names: | mitochondrial ribosomal protein S30 |
NCBI Official Symbol: | MRPS30 |
NCBI Official Synonym Symbols: | PAP; PDCD9; S30mt; MRP-S30 |
NCBI Protein Information: | 28S ribosomal protein S30, mitochondrial; programmed cell death 9 |
UniProt Protein Name: | 28S ribosomal protein S30, mitochondrial |
UniProt Synonym Protein Names: | Programmed cell death protein 9 |
Protein Family: | 28S ribosomal protein |
UniProt Gene Name: | MRPS30 |
UniProt Entry Name: | RT30_HUMAN |