Cell Biology Antibodies 10

MMRN1 Rabbit Polyclonal Antibody (CAB6658)

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SKU:
CAB6658
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse
Synonyms:
ECM, MMRN, GPIa*, EMILIN4, MMRN1
Research Use:
Cell Biology
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Description

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MMRN1 Antibody (CAB6658)

The MMRN1 Antibody (CAB6658) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity to human Multimerin-1, making it a reliable choice for Western blot applications.Multimerin-1 is important in the regulation of hemostasis and thrombosis, and its dysregulation has been linked to various bleeding disorders and cardiovascular diseases. By targeting Multimerin-1 with this antibody, researchers can explore its role in these physiological processes and potentially identify new therapeutic targets for clotting disorders.Furthermore, the Multimerin-1 Polyclonal Antibody (CAB6658) offers researchers the opportunity to investigate Multimerin-1's potential involvement in cancer progression, as aberrant expression of this protein has been observed in certain cancer types.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:MMRN1 Antibody
SKU:CAB6658
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:ENAL APDF SKGS YRYA PMVA FFAS HTYG MTIP GPIL FNNL DVNY GASY TPRT GKFR IPYL GVYV FKYT IESF SAHI SGFL VVDG IDKL AFES ENIN SEIH CDRV LTGD ALLE LNYG QEVW LRLA KGTI PAKF PPVT TFSG YLLY RT
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:100
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:ECM, MMRN, GPIa*, EMILIN4, MMRN1
Positive Sample:HepG2, U-251MG, Mouse lung, Mouse spleen
Cellular Localization:Secreted.
Calculated MW:138kDa
Observed MW:180kDa

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin.

Purification MethodAffinity purification
Gene ID22915
RRIDAB_2767245
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using MMRN1 Rabbit pAb (CAB6658) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC):U-251 MG Exposure time: 180s.
Product ImageImmunofluorescence analysis of U2OS cells using MMRN1 Rabbit pAb (CAB6658). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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