The MERTK Monoclonal Antibody (CAB12294) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced using rabbit monoclonal technology, is highly specific and sensitive for detecting MERTK in human samples. It has been validated for use in various applications, including Western blotting, immunohistochemistry, and flow cytometry.MERTK, also known as c-Mer proto-oncogene tyrosine kinase, plays a crucial role in the clearance of apoptotic cells and the regulation of immune tolerance. Dysregulation of MERTK signaling has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
MERTK Monoclonal Antibody
SKU:
CAB12294
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC0229
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MER, RP38, c-Eyk, c-mer, Tyro12, MERTK
Positive Sample:
Hep G2
Cellular Localization:
Cell Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
110kDa
Observed MW:
150-200kDa
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Purification Method
Affinity purification
Gene ID
10461
RRID
AB_2861648
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from HepG2 cells, using MERTK Rabbit mAb (CAB12294) at 1：1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
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